Notch ligand functionalized microbead system for T cell differentiation
نویسندگان
چکیده
............................................... Pg. 4 Introduction ................................................ Pg. 6 Materials and Methods ................................................ Pg. 17 Results ................................................ Pg. 20 Discussion ................................................ Pg. 28 References ................................................ Pg. 34
منابع مشابه
Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength
In humans, high Notch activation promotes γδ T cell development, whereas lower levels promote αβ-lineage differentiation. How these different Notch signals are generated has remained unclear. We show that differential Notch receptor-ligand interactions mediate this process. Whereas Delta-like 4 supports both TCR-αβ and -γδ development, Jagged1 induces mainly αβ-lineage differentiation. In contr...
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